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Background
Most breast cancers (BCs) in men are hormone receptor–positive. Adjuvant tamoxifen is part of the standard treatment of these patients. Small, single‐institution studies have suggested that men have high rates of discontinuing adjuvant endocrine treatment. The authors examined rates of tamoxifen discontinuation and medication adherence in a large population‐based cohort of male patients...
The 2016 revised fourth edition of the World Health Organization (WHO) classification of central nervous system (CNS) tumors incorporated molecular features with histologic grading, revolutionizing how oncologists conceptualize primary brain and spinal cord tumors as well as providing new insights into their management and prognosis. The 2021 revised fifth edition of the WHO classification further...
Background
The goal of this study was to characterize cannabis use among patients with breast cancer, including their reasons for and timing of use, their sources of cannabis information and products, their satisfaction with the information found, their perceptions of its safety, and their dialogue about cannabis with their physicians.
Methods
United States–based members of the Breastcancer.org...
Background
Breast cancer (BrCa) outcomes vary by social environmental factors, but the role of built‐environment factors is understudied. The authors investigated associations between environmental physical disorder—indicators of residential disrepair and disinvestment—and BrCa tumor prognostic factors (stage at diagnosis, tumor grade, triple‐negative [negative for estrogen receptor, progesterone...
Background
Poly(ADP‐ribose) polymerase (PARP) inhibitors may synergize with programmed cell death receptor‐1 (PD‐1) inhibitors to enhance adaptive and innate antitumor immune responses. In the phase 2 JASPER study (NCT03308942), the PARP inhibitor niraparib was evaluated in combination with the PD‐1 inhibitor pembrolizumab in patients with metastatic and/or locally advanced non–small cell lung cancer...
Background
Social determinants of health (SDOHs) cluster together and can have deleterious impacts on health outcomes. Individually, SDOHs increase the risk of cancer mortality, but their cumulative burden is not well understood. The authors sought to determine the combined effect of SDOH on cancer mortality.
Methods
Using the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort,...
Background
Little is known about cancer survivors who discontinue survivorship care. The objective of this study was to characterize patients with head and neck cancer who discontinue survivorship care with their treating institution and identify factors associated with discontinuation.
Methods
This was a retrospective cohort study of patients diagnosed with head and neck cancer between January...
Background
Patient‐centered approaches to research design are particularly important for diseases with complex treatment decision‐making, such as recurrent, high‐grade non–muscle‐invasive bladder cancer (NMIBC). The objective of this article is to describe patient and public involvement (PPI) in designing a large, pragmatic observational trial and to articulate barriers, challenges, and lessons learned...
Background
The value of neoadjuvant chemotherapy in soft tissue sarcoma (STS) is not completely understood. This study investigated the benefit of neoadjuvant chemotherapy according to prognostic stratification based on the Sarculator nomogram for STS.
Methods
This study analyzed data from ISG‐STS 1001, a randomized study that tested 3 cycles of neoadjuvant anthracycline plus ifosfamide (AI) or...
Lay Summary
Sarculator is better at predicting patients with sarcoma at the highest risk of death than current staging systems and should be used to determine appropriate patients for future studies.
Background
Tobacco dependence, alcohol abuse, depression, distress, and other adverse patient‐level influences are common in head and neck cancer (HNC) survivors. Their interrelatedness and precise burden in comparison with survivors of other cancers are poorly understood.
Methods
National Health Interview Survey data from 1997 to 2016 were pooled. The prevalence of adverse patient‐level influences...
Background
The objective of this study was to determine the impact of seizure‐related factors on neurocognitive, health‐related quality of life (HRQOL), and social outcomes in survivors of childhood cancer.
Methods
Survivors of childhood cancer treated at St. Jude Children's Hospital (n = 2022; 48.3% female; median age, 31.5 years; median time since diagnosis, 23.6 years) completed neurocognitive...
Background
Traditionally, conventional induction chemotherapy has been the primary frontline treatment for acute myeloid leukemia (AML); however, older adults are often poor chemotherapy candidates. Recently, several nonconventional frontline AML regimens, including hypomethylating agents, the BCL‐2 inhibitor venetoclax, and targeted therapies, have emerged, and they may offer new options for older...
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